Nanoethosomal formulation of gammaoryzanol for skin-aging protection and wrinkle improvement: a histopathological study

Background: Free radical scavengers and antioxidants, with the main focus on enhanced targeting to the skin layers, can provide protection against skin ageing.

Objective: The aim of the present study was to prepare nanoethosomal formulation of gammaoryzanol (GO), a water insoluble antioxidant, for its dermal delivery to prevent skin aging.

Methods: Nanoethosomal formulation was prepared by a modified ethanol injection method and characterized by using laser light scattering, scanning electronic microscope (SEM) and X-ray diffraction (XRD) techniques. The effects of formulation parameters on nanoparticle size, encapsulation efficiency percent (EE%) and loading capacity percent (LC%) were investigated. Antioxidant activity of GO-loaded formulation was investigated in vitro using normal African green monkey kidney fibroblast cells (Vero). The effect of control and GO-loaded nanoethosomal formulation on superoxide dismutase (SOD) and malondialdehyde (MDA) content of rat skin was also probed. Furthermore, the effect of GO-loaded nanoethosomes on skin wrinkle improvement was studied by dermoscopic and histological examination on healthy humans and UV-irradiated rats, respectively.

Results: The optimized nanoethosomal formulation showed promising characteristics including narrow size distribution 0.17?±?0.02, mean diameter of 98.9?±?0.05?nm, EE% of 97.12?±?3.62%, LC% of 13.87?±?1.36% and zeta potential value of –15.1?±?0.9?mV. The XRD results confirmed uniform drug dispersion in the nanoethosomes structure. In vitro and in vivo antioxidant studies confirmed the superior antioxidant effect of GO-loaded nanoethosomal formulation compared with control groups (blank nanoethosomes and GO suspension).

Conclusions: Nanoethosomes was a promising carrier for dermal delivery of GO and consequently had superior anti-aging effect.     

Successive melting and crystallization of poly(3-hexylthiophene) in the melt-memory domain versus isotropic melt domain

Journal of Materials Science - We studied the influence of self-nuclei of poly(3-hexylthiophene), present at different temperatures in the melt-memory domain, and thermal polymer degradation during...     

An analytical model for the combustion of coal particles

A model for the combustion of coal particles is developed which accounts for the gasification and pyrolysis reactions throughout the particles, oxidation reactions at the particles' outer surface, distributed gas-phase reactions around the particles, and transport of heat and mass throughout the reaction zones. The model shows that the combustion of large particles is dominated by gasification and gas-phase reactions. As large particles burn and shrink, however, the mechanism changes to one dominated by surface oxidation. This change in mechanism can be gradual or very rapid (even discontinuous) depending on the combustion conditions. The particle size at which this transition takes place decreases as the bulk gas temperature or oxygen concentration increase. The proposed model is used to predict the conversion of pulverized coal as a function of time; the results agree with literature data for particles of 26-32 μm radius.     

A Variable Current-Limit Control Scheme for a Bi-directional Converter used in Ultracapacitor Applications

In ultracapacitor applications, generally, a bi-directional converter is connected to a DC bus and is designed to compensate rapid load variations on the bus. During transient phases, overloaded DC bus can push the converter out of its operating limits. For providing the necessary power, converters should be put in parallel, while each converter is limited into its optimal operating range. In a boost converter, this operating limit can be related to the inductor current and UC voltage. In this study, a variable current-limit is proposed for inductor current which then determines the operating range of the boost converter. This method will provide stability of the converter during overload transients. An experimental setup consisting of a bi-directional converter, a controllable load/source, and an ultracapacitor is presented, to validate the proposed method. Several scenarii are applied to analyze the performance of the system in overloaded phases and theoretical and experimental results are presented.     

Prediction of rotary drilling penetration rate in iron ore oxides using rock engineering system

Prediction of the drilling penetration rate is one of the important parameters in mining operations. This parameter has a direct impact on the mine planning and cost of mining operations. Generally, effective parameters on the penetration rate is divided into two classes: rock mass properties and specifications of the machine. The chemical components of intact rock have a direct effect in determining rock mechanical properties. Theses parameters usually have not been investigated in any research on the rock drillability. In this study, physical and mechanical properties of iron ore were studied based on the amount of magnetite percent. According to the results of the tests, the effective parameters on the penetration rate of the rotary drilling machines were divided into three classes: specifications of the machines, rock mass properties and chemical component of intact rock. Then, the rock drillability was studied using rock engineering systems. The results showed that feed, rotation, rock mass index and iron oxide percent have important effect on penetration rate. Then a quadratic equation with 0.896 determination coefficient has been obtained. Also, the results showed that chemical components can be described as new parameters in rotary drill penetration rate.     

Development of nano-channel single crystals and verification of their structures by small angle X-ray scattering

Nano-channel single crystals were developed via consecutive growth of various polymer single-crystal channels comprising homo and block copolymers by self-seeding method. Poly(ethylene glycol)-b-polystyrene (PEG-b-PS) and poly(ethylene glycol)-b-poly(methyl methacrylate) (PEG-b-PMMA) block copolymers were synthesized by atom transfer radical polymerization. Self-seeding temperature, concentration, and crystallization time affected the width of the channels. This might provide a new way to investigate directional absorption, diffusion, and immobilization of biomacromolecules on the surface. The crystalline blocks of PEG-b-PS and PEG-b-PMMA diblock copolymers were similar, therefore, the continuity of channel-wire growth was guaranteed. Development of complete square channels next to the channels covered with high molecular weight brushes was infeasible. It was ascribed to a higher hindrance of primarily existing tethered chains on the single-crystal channel. Finally, the consecutive channel-wire single crystals were compared with single-step-grown pyramidal and conic structures. These multilayer crystals grew spirally and formed non-flat channels. The structure and morphology of different crystalline channels were detected by atomic force microscopy (AFM) and small angle X-ray scattering (SAXS). In this work, for the first time, the SAXS data of channel-wire single crystals were reported and they were compared by non-flat channel-like crystals. A profound investigation of PEG-b-PS, PEG-b-PMMA copolymers and PEG homopolymer channel-wire single crystals by SAXS and their comparison with AFM data was a novel work in the field of single-crystal engineering.     

ABSs系统模糊控制器优化设计

已经开发了的ABSs系统改善了突然制动和特别是滑动路面状况时车辆控制。这样的控制目标是在保持车辆合适稳定性及可操纵性和缩短车辆刹车距离情况下在要求的方向增大车轮的牵引力。本文提出了ABSs系统优化的模糊控制器。从保持其车轮滑动值为目标函数获得车轮最大的牵引力和车轮最大的减速度。采用遗传算法优化模糊系统的全部组件。采用误差数整体优化方法收敛接近最优点。仿真结果表明快速收敛和对不同路况的控制器的最好性能。     

Orientation variance discrimination in amblyopia

Our previous results showed that while amblyopes can efficiently integrate visual signals, they are poor at segregating signals in noise. This could be either because integration detectors have broader bandwidths or because of a selective extrastriate segregation anomaly. One consequence of the former would be poorer variance discrimination. Using a two-alternative forced-choice paradigm, observers were asked to judge the orientational variance for arrays of 16 Gabors. All observers, be they normal or amblyopic, could perform the task similarly, although at high spatial frequencies, amblyopic eyes needed slightly more incremental variance than the normal eyes. We conclude that normals and amblyopes integrate signals in a similar way.